Dengue Virus Type 2 (DENV2)-Induced Oxidative Responses in Monocytes from Glucose-6-Phosphate Dehydrogenase (G6PD)-Deficient and G6PD Normal Subjects
Identifieur interne : 000A39 ( Main/Exploration ); précédent : 000A38; suivant : 000A40Dengue Virus Type 2 (DENV2)-Induced Oxidative Responses in Monocytes from Glucose-6-Phosphate Dehydrogenase (G6PD)-Deficient and G6PD Normal Subjects
Auteurs : Abdullah Ahmed Al-Alimi [Malaisie] ; Syed A. Ali [Malaisie] ; Faisal Muti Al-Hassan [Malaisie] ; Fauziah Mohd Idris [Malaisie] ; Sin-Yeang Teow [Malaisie] ; Narazah Mohd Yusoff [Malaisie]Source :
- PLoS Neglected Tropical Diseases [ 1935-2727 ] ; 2014.
Abstract
Dengue virus is endemic in peninsular Malaysia. The clinical manifestations vary depending on the incubation period of the virus as well as the immunity of the patients. Glucose-6-phosphate dehydrogenase (G6PD) deficiency is prevalent in Malaysia where the incidence is 3.2%. It has been noted that some G6PD-deficient individuals suffer from more severe clinical presentation of dengue infection. In this study, we aim to investigate the oxidative responses of DENV2-infected monocytes from G6PD-deficient individuals.
Monocytes from G6PD-deficient individuals were infected with DENV2 and infection rate, levels of oxidative species, nitric oxide (NO), superoxide anions (O2−), and oxidative stress were determined and compared with normal controls.
Monocytes from G6PD-deficient individuals exhibited significantly higher infection rates compared to normal controls. In an effort to explain the reason for this enhanced susceptibility, we investigated the production of NO and O2− in the monocytes of individuals with G6PD deficiency compared with normal controls. We found that levels of NO and O2− were significantly lower in the DENV-infected monocytes from G6PD-deficient individuals compared with normal controls. Furthermore, the overall oxidative stress in DENV-infected monocytes from G6PD-deficient individuals was significantly higher when compared to normal controls. Correlation studies between DENV-infected cells and oxidative state of monocytes further confirmed these findings.
Altered redox state of DENV-infected monocytes from G6PD-deficient individuals appears to augment viral replication in these cells. DENV-infected G6PD-deficient individuals may contain higher viral titers, which may be significant in enhanced virus transmission. Furthermore, granulocyte dysfunction and higher viral loads in G6PD-deificient individuals may result in severe form of dengue infection.
Url:
DOI: 10.1371/journal.pntd.0002711
PubMed: 24625456
PubMed Central: 3953068
Affiliations:
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Ali</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Penang, Malaysia</addr-line></nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Penang</wicri:regionArea><wicri:noRegion>Penang</wicri:noRegion></affiliation></author><author><name sortKey="Al Hassan, Faisal Muti" sort="Al Hassan, Faisal Muti" uniqKey="Al Hassan F" first="Faisal Muti" last="Al-Hassan">Faisal Muti Al-Hassan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Penang, Malaysia</addr-line></nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Penang</wicri:regionArea><wicri:noRegion>Penang</wicri:noRegion></affiliation></author><author><name sortKey="Idris, Fauziah Mohd" sort="Idris, Fauziah Mohd" uniqKey="Idris F" first="Fauziah Mohd" last="Idris">Fauziah Mohd Idris</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Microbiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia</addr-line></nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Microbiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan</wicri:regionArea><wicri:noRegion>Kelantan</wicri:noRegion></affiliation></author><author><name sortKey="Teow, Sin Yeang" sort="Teow, Sin Yeang" uniqKey="Teow S" first="Sin-Yeang" last="Teow">Sin-Yeang Teow</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Penang, Malaysia</addr-line></nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Penang</wicri:regionArea><wicri:noRegion>Penang</wicri:noRegion></affiliation></author><author><name sortKey="Mohd Yusoff, Narazah" sort="Mohd Yusoff, Narazah" uniqKey="Mohd Yusoff N" first="Narazah" last="Mohd Yusoff">Narazah Mohd Yusoff</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Penang, Malaysia</addr-line></nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Penang</wicri:regionArea><wicri:noRegion>Penang</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24625456</idno><idno type="pmc">3953068</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953068</idno><idno type="RBID">PMC:3953068</idno><idno type="doi">10.1371/journal.pntd.0002711</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000670</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000670</idno><idno type="wicri:Area/Pmc/Curation">000670</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000670</idno><idno type="wicri:Area/Pmc/Checkpoint">000417</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000417</idno><idno type="wicri:Area/Ncbi/Merge">000376</idno><idno type="wicri:Area/Ncbi/Curation">000376</idno><idno type="wicri:Area/Ncbi/Checkpoint">000376</idno><idno type="wicri:doubleKey">1935-2727:2014:Al Alimi A:dengue:virus:type</idno><idno type="wicri:Area/Main/Merge">000A41</idno><idno type="wicri:Area/Main/Curation">000A39</idno><idno type="wicri:Area/Main/Exploration">000A39</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Dengue Virus Type 2 (DENV2)-Induced Oxidative Responses in Monocytes from Glucose-6-Phosphate Dehydrogenase (G6PD)-Deficient and G6PD Normal Subjects</title><author><name sortKey="Al Alimi, Abdullah Ahmed" sort="Al Alimi, Abdullah Ahmed" uniqKey="Al Alimi A" first="Abdullah Ahmed" last="Al-Alimi">Abdullah Ahmed Al-Alimi</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Penang, Malaysia</addr-line></nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Penang</wicri:regionArea><wicri:noRegion>Penang</wicri:noRegion></affiliation></author><author><name sortKey="Ali, Syed A" sort="Ali, Syed A" uniqKey="Ali S" first="Syed A." last="Ali">Syed A. Ali</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Penang, Malaysia</addr-line></nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Penang</wicri:regionArea><wicri:noRegion>Penang</wicri:noRegion></affiliation></author><author><name sortKey="Al Hassan, Faisal Muti" sort="Al Hassan, Faisal Muti" uniqKey="Al Hassan F" first="Faisal Muti" last="Al-Hassan">Faisal Muti Al-Hassan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Penang, Malaysia</addr-line></nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Penang</wicri:regionArea><wicri:noRegion>Penang</wicri:noRegion></affiliation></author><author><name sortKey="Idris, Fauziah Mohd" sort="Idris, Fauziah Mohd" uniqKey="Idris F" first="Fauziah Mohd" last="Idris">Fauziah Mohd Idris</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Microbiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia</addr-line></nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Microbiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan</wicri:regionArea><wicri:noRegion>Kelantan</wicri:noRegion></affiliation></author><author><name sortKey="Teow, Sin Yeang" sort="Teow, Sin Yeang" uniqKey="Teow S" first="Sin-Yeang" last="Teow">Sin-Yeang Teow</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Penang, Malaysia</addr-line></nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Penang</wicri:regionArea><wicri:noRegion>Penang</wicri:noRegion></affiliation></author><author><name sortKey="Mohd Yusoff, Narazah" sort="Mohd Yusoff, Narazah" uniqKey="Mohd Yusoff N" first="Narazah" last="Mohd Yusoff">Narazah Mohd Yusoff</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Penang, Malaysia</addr-line></nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Penang</wicri:regionArea><wicri:noRegion>Penang</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS Neglected Tropical Diseases</title><idno type="ISSN">1935-2727</idno><idno type="eISSN">1935-2735</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Dengue virus is endemic in peninsular Malaysia. The clinical manifestations vary depending on the incubation period of the virus as well as the immunity of the patients. Glucose-6-phosphate dehydrogenase (G6PD) deficiency is prevalent in Malaysia where the incidence is 3.2%. It has been noted that some G6PD-deficient individuals suffer from more severe clinical presentation of dengue infection. In this study, we aim to investigate the oxidative responses of DENV2-infected monocytes from G6PD-deficient individuals.</p></sec><sec><title>Methodology</title><p>Monocytes from G6PD-deficient individuals were infected with DENV2 and infection rate, levels of oxidative species, nitric oxide (NO), superoxide anions (O<sub>2</sub><sup>−</sup>), and oxidative stress were determined and compared with normal controls.</p></sec><sec><title>Principal Findings</title><p>Monocytes from G6PD-deficient individuals exhibited significantly higher infection rates compared to normal controls. In an effort to explain the reason for this enhanced susceptibility, we investigated the production of NO and O<sub>2</sub><sup>−</sup> in the monocytes of individuals with G6PD deficiency compared with normal controls. We found that levels of NO and O<sub>2</sub><sup>−</sup> were significantly lower in the DENV-infected monocytes from G6PD-deficient individuals compared with normal controls. Furthermore, the overall oxidative stress in DENV-infected monocytes from G6PD-deficient individuals was significantly higher when compared to normal controls. Correlation studies between DENV-infected cells and oxidative state of monocytes further confirmed these findings.</p></sec><sec><title>Conclusions/Significance</title><p>Altered redox state of DENV-infected monocytes from G6PD-deficient individuals appears to augment viral replication in these cells. DENV-infected G6PD-deficient individuals may contain higher viral titers, which may be significant in enhanced virus transmission. 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sortKey="Nisalak, A" uniqKey="Nisalak A">A Nisalak</name></author><author><name sortKey="Chunsuttitwat, S" uniqKey="Chunsuttitwat S">S Chunsuttitwat</name></author><author><name sortKey="Vaughn, Dw" uniqKey="Vaughn D">DW Vaughn</name></author><author><name sortKey="Green, S" uniqKey="Green S">S Green</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Avirutnan, P" uniqKey="Avirutnan P">P Avirutnan</name></author><author><name sortKey="Punyadee, N" uniqKey="Punyadee N">N Punyadee</name></author><author><name sortKey="Noisakran, S" uniqKey="Noisakran S">S Noisakran</name></author><author><name sortKey="Komoltri, C" uniqKey="Komoltri C">C Komoltri</name></author><author><name sortKey="Thiemmeca, S" uniqKey="Thiemmeca S">S Thiemmeca</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fox, A" uniqKey="Fox A">A Fox</name></author><author><name sortKey="Le, Nm" uniqKey="Le N">NM Le</name></author><author><name sortKey="Simmons, Cp" uniqKey="Simmons C">CP Simmons</name></author><author><name sortKey="Wolbers, M" uniqKey="Wolbers M">M Wolbers</name></author><author><name sortKey="Wertheim, Hf" uniqKey="Wertheim H">HF Wertheim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Bruggen, R" uniqKey="Van Bruggen R">R van Bruggen</name></author><author><name sortKey="Bautista, Jm" uniqKey="Bautista J">JM Bautista</name></author><author><name sortKey="Petropoulou, T" uniqKey="Petropoulou T">T Petropoulou</name></author><author><name sortKey="De Boer, M" uniqKey="De Boer M">M de Boer</name></author><author><name sortKey="Van Zwieten, R" uniqKey="Van Zwieten R">R van Zwieten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nkhoma, Et" uniqKey="Nkhoma E">ET Nkhoma</name></author><author><name sortKey="Poole, C" uniqKey="Poole C">C Poole</name></author><author><name sortKey="Vannappagari, V" uniqKey="Vannappagari V">V Vannappagari</name></author><author><name sortKey="Hall, Sa" uniqKey="Hall S">SA Hall</name></author><author><name sortKey="Beutler, E" uniqKey="Beutler E">E Beutler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De La C Sierra, B" uniqKey="De La C Sierra B">B de la C Sierra</name></author><author><name sortKey="Garcia, G" uniqKey="Garcia G">G García</name></author><author><name sortKey="Perez, Ab" uniqKey="Perez A">AB Pérez</name></author><author><name sortKey="Morier, L" uniqKey="Morier L">L Morier</name></author><author><name sortKey="Alvarez, M" uniqKey="Alvarez M">M Alvarez</name></author><author><name sortKey="Kouri, G" uniqKey="Kouri G">G Kourí</name></author><author><name sortKey="Guzman, Mg" uniqKey="Guzman M">MG Guzmán</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De La C Sierra, B" uniqKey="De La C Sierra B">B de la C Sierra</name></author><author><name sortKey="Kouri, G" uniqKey="Kouri G">G Kourí</name></author><author><name sortKey="Guzman, Mg" uniqKey="Guzman M">MG Guzmán</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Malaisie</li></country></list><tree><country name="Malaisie"><noRegion><name sortKey="Al Alimi, Abdullah Ahmed" sort="Al Alimi, Abdullah Ahmed" uniqKey="Al Alimi A" first="Abdullah Ahmed" last="Al-Alimi">Abdullah Ahmed Al-Alimi</name></noRegion><name sortKey="Al Hassan, Faisal Muti" sort="Al Hassan, Faisal Muti" uniqKey="Al Hassan F" first="Faisal Muti" last="Al-Hassan">Faisal Muti Al-Hassan</name><name sortKey="Ali, Syed A" sort="Ali, Syed A" uniqKey="Ali S" first="Syed A." last="Ali">Syed A. Ali</name><name sortKey="Idris, Fauziah Mohd" sort="Idris, Fauziah Mohd" uniqKey="Idris F" first="Fauziah Mohd" last="Idris">Fauziah Mohd Idris</name><name sortKey="Mohd Yusoff, Narazah" sort="Mohd Yusoff, Narazah" uniqKey="Mohd Yusoff N" first="Narazah" last="Mohd Yusoff">Narazah Mohd Yusoff</name><name sortKey="Teow, Sin Yeang" sort="Teow, Sin Yeang" uniqKey="Teow S" first="Sin-Yeang" last="Teow">Sin-Yeang Teow</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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